Endocrine Abstracts

The higher risk of cardiovascular mortality in women with Turner Syndrome (TS) is partly related to their risk of aortic dissection, which causes death in 1: 50 women. Establishing factors which predict increased risk of aortic dissection is therefore of prime importance. Previous studies have suggested that multiple risk factors exist, notably coarctation, aortic root dilatation, bicuspid aortic valve and systemic hypertension.In this study we focused ...

IntroductionWomen with Turner Syndrome (TS), characterised by the complete or partial absence of one X-chromosome in females, are reported to have an increased risk of coeliac disease, inflammatory bowel disease and angiodysplasia. These may contribute to iron deficiency and anaemia through malabsorption or blood loss. This study screened the serum ferritin and haemoglobin measurements in an adult TS population.MethodSerum ferritin concentrations were measured in 1...

IntroductionWomen with Turner Syndrome have an increased prevalence of hearing loss. Conductive hearing loss (CHL) is thought to be caused by craniofacial abnormalities or defective mucociliary transport resulting in impaired middle ear ventilation, increased otitis media and tympanic perforations. Sensorineural hearing loss (SNHL) progresses with age, possibly due to premature aging. An adult population was assessed for the impact of childhood treatment...

IntroductionWomen with Turner Syndrome have an increased prevalence of hearing loss. Conductive hearing loss (CHL) is thought to be caused by craniofacial abnormalities or defective mucociliary transport resulting in impaired middle ear ventilation, increased otitis media and tympanic perforations. Sensorineural hearing loss (SNHL) progresses with age, possibly due to premature aging. An adult population was assessed for the impact of childhood treatment...

IntroductionWomen with Turner Syndrome (TS) have an increased risk of diabetes mellitus (DM), both types 1 and 2, and obesity is a common problem. This study aimed to characterise the relationship between markers of obesity and metabolic factors which might predispose to DM.MethodAnthropometric and fasting metabolic assessments were performed in 56 non-diabetic women with TS and 24 control women (mean±...

IntroductionCardiovascular complications are the main cause of increased mortality in Turner Syndrome (TS). We have previously described a high prevalence of occult aortic dysmorphology in women with TS. The aim of this study was to introduce a classification system for the variety of appearances seen by magnetic resonance imaging (MRI).Method98 women (median age 29.0, range 18.1-64.2 years) underwent MRI scanning of the aorta. MRI appearances were correlated with ...

IntroductionCardiovascular disease, which may be structural or ischaemic, is the major cause of morbidity and mortality for women with Turner Syndrome (TS). This study investigated arterial augmentation index (AI%) and pulse wave velocity (PWV) as measures of arterial stiffness in adults with TS. A more positive AI% and greater PWV indicate increased arterial stiffness.Method66 women with TS and 8 normal wome...

IntroductionCardiovascular disease, which may be structural or ischaemic, is the major cause of morbidity and mortality for women with Turner Syndrome (TS). This study investigated arterial augmentation index (AI%) and pulse wave velocity (PWV) as measures of arterial stiffness in adults with TS. A more positive AI% and greater PWV indicate increased arterial stiffness.Method66 women with TS and 8 normal wome...